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Independent comparison · Last updated October 2026

Online GLP-1 programs, compared side by side (2026)

See the top 5 Find my fit in 3 questions

Editorial disclosure

We research each program ourselves. If you sign up through our links we may earn a commission at no cost to you. Compensation, including paid featured placements, can affect rankings and scores.

We started by comparing 15 GLP-1 and medical weight-management programs available online. We looked beyond the headline price and compared what people actually get for their money: the medical consultation process, medication options, ongoing provider support, recurring fees, shipping costs, cancellation policies, and what happens if a patient isn't prescribed treatment.

The differences were bigger than we expected. One stood out for their combination of transparent pricing, access to licensed medical providers, ongoing support, and overall simplicity.

We've narrowed the field to five programs below and explain how each compares. Our rankings consider factors such as clinical care, medication access, price transparency, and ongoing support—not promises of a particular weight-loss result. Eligibility and treatment are determined by a licensed healthcare provider, and results vary from person to person.

Scroll down to compare the five programs, see what each includes, and decide which options are worth discussing with a healthcare professional.

Before you compare: GLP-1 medications are available only after a medical evaluation by a licensed clinician, and they aren't right for everyone, including people with a personal or family history of medullary thyroid carcinoma or MEN 2. Common side effects include nausea, vomiting and diarrhea. Results vary. We're not endorsed by any brand here; trademarks belong to their owners. Medical disclaimer

Featured partner · Best all-inclusive monthly price

DirectMeds

One monthly price that includes the medication, doctor visits, supplies and shipping, with compounded medication. Formulation varies by provider.

overall★★★★★

Why it stands out

One monthly price covers medication, doctor visits, supplies and shipping, with no membership fee
$150 off the first month: the selected compounded treatment is $147 to start
Formulation varies by provider
A licensed doctor reviews your intake within 24 hours
Refund policy in DirectMeds' terms
LegitScript certified; ships from U.S.-based 503A compounding pharmacies in 1–2 days

Worth knowing

No brand-name options
Not available in Mississippi or Louisiana; doesn't take insurance

Clinical care9.6
Medication access9.5
Price transparency9.8
Ongoing support9.6

BEST FOR SIMPLE PRICING

TrimRx

Online GLP-1 care with no monthly membership fee, same-price dosing, free shipping, and online doctor visits included.

overall

TrimRx

Why it stands out

No monthly membership fee
Same price at every dose with no hidden fees
Doctor visits are included
Free shipping is included
No insurance is required
Cancel anytime to stop future orders, but cancelling alone doesn't trigger a refund
Licensed medical providers evaluate eligibility and prescribe when appropriate

Worth knowing

Compounded medications are not FDA-approved
TrimRx also allows providers to prescribe FDA-approved branded medications, but TrimRx does not dispense or ship those branded medications
If prescribed a branded medication, the patient is responsible for filling it at a pharmacy and paying the associated medication cost

Clinical care9.4
Medication access9.4
Price transparency9.5
Ongoing support9.3

Best for compounded + brand-name options

MEDGm

Compounded and brand-name GLP-1s with labs included and clear pricing.

overall

Why it stands out

Compounded GLP-1 injections start at $169; oral tablets start at $239
Brand-name medications for a $99 membership plus medication cost
Labs included, with licensed medical providers and provider-led coaching
Free, expedited delivery to your door
Full refund if a provider disqualifies you for a medical reason
HSA/FSA accepted; LegitScript certified

Worth knowing

Compounded medications are not FDA-approved and haven't been evaluated for safety, efficacy or quality
Brand-name medication costs are billed on top of the $99 membership
A licensed provider decides whether treatment is appropriate

Clinical care9.4
Medication access9.3
Price transparency9.3
Ongoing support9.2

Best for one price at every dose

Pallas Health

No membership fee and the same compounded price at every dose, plus brand-name options.

overall

Why it stands out

No membership fee: provider visits, follow-ups and messaging included
Selected compounded treatment from $139 the first month, then $199 every 4 weeks or about $139/mo on the annual plan
One price at every dose on compounded plans
Free, discreet shipping from U.S. pharmacies; cancel anytime
Full refund if a clinician doesn't approve your plan; the order is final after a clinician prescribes; FSA/HSA eligible; LegitScript certified

Worth knowing

Compounded medications are not FDA-approved and are not generic versions of brand-name drugs
Brand-name medications are cash-pay and expensive (one listed at $1,349/mo)
Doesn't bill insurance; 7 states plus Washington, D.C. require one video visit to start

Clinical care9.1
Medication access9.2
Price transparency9.2
Ongoing support8.9

Best for 24/7 care team access

Trimi

Medication, supplies, provider care and shipping in one plan, with a care team available 24/7.

overall

Why it stands out

Medication, supplies, provider care and shipping included in one plan
Selected compounded treatment from $99/mo on the 12-month plan
Monthly, 3-, 6- and 12-month plans available
Care team available 24/7, with replies within 1 hour
Free overnight shipping once your medication is compounded
6-month money-back policy (see Trimi's terms); LegitScript certified

Worth knowing

Compounded medications are not FDA-approved; the FDA doesn't review them for safety, effectiveness or quality
The lowest prices require a 12-month plan; monthly plans cost more
No brand-name medication options

Clinical care8.9
Medication access8.8
Price transparency8.9
Ongoing support9.2

Find your fit

Not sure which one? Answer three questions.

Every program above suits a different kind of person. Tell us what matters to you and we'll point you to a good place to start. This isn't medical advice; a clinician makes the final call.

1. Do you plan to use health insurance? Yes No, I'll pay myself Not sure

2. Which medications are you open to? FDA-approved brand-name only Open to compounded Not sure yet

3. What matters most to you? Lowest, predictable price Nutrition coaching Fast access to my care team

How we scored them

Every program is scored on the same four criteria. We don't take medications ourselves or publish personal weight-loss results; we compare programs as services, using public pricing and each program's own sign-up flow.

30%Clinical care

25%Medication access

25%Price transparency

20%Ongoing support

Clinical care. Clinician credentials, depth of review, labs and how fast you can reach someone about side effects.

Medication access. Which FDA-approved GLP-1s are available, and whether compounded options are clearly labeled.

Price transparency. Total monthly cost shown up front, price changes with dose, and cancellation terms.

Ongoing support. Coaching, nutrition help, check-ins and app quality.

Why we feature DirectMeds

DirectMeds is our featured partner, which means it pays for its position on this page, and compensation can affect rankings and scores. What stands out is how simple the pricing is: one monthly price covers the medication, doctor visits, supplies and shipping.

All-inclusive pricing

Most programs charge a membership and bill medication separately. The selected compounded treatment costs $297 a month. That price includes the medication, doctor visits, supplies and shipping, with no separate membership fee. New patients get $150 off the first month, so the selected treatment starts at $147. Refund policy in DirectMeds' terms.

Fast review and delivery

You complete a 5-minute health qualifier, choose a medication and pay for the first month, then finish a medical intake in the patient portal. A licensed doctor reviews it within 24 hours and decides whether treatment is appropriate. Doctor visits are included in the price, and support is available by phone (888-696-7176) and email. Approved treatment ships from U.S.-based 503A compounding pharmacies, usually within 1–2 days.

Medication choice

Doctors can prescribe compounded medication. Formulation varies by provider. Compounded medications are not FDA-approved and are not generic versions of brand-name drugs. Ask your doctor which formulation they prescribe and why.

Things to weigh

DirectMeds doesn't offer brand-name medications or take insurance, and it isn't available in Mississippi or Louisiana. After the first month its price is higher than some programs on this list, including Pallas Health. It is LegitScript certified, which means its pharmacy and prescribing practices have been independently reviewed.

A licensed clinician decides whether a GLP-1 medication is right for you.

Questions people ask

What are GLP-1 medications?

GLP-1 receptor agonists are medications that mimic a hormone involved in appetite and blood sugar regulation. Some are FDA-approved for chronic weight management in adults who meet specific criteria, and others are approved for type 2 diabetes. Only a licensed clinician can decide whether one is appropriate for you.

Do these programs guarantee treatment?

No. Every provider on this list requires a medical evaluation, and a clinician may decide a GLP-1 medication is not right for you. Reputable programs will tell you that up front.

What side effects should I know about?

Commonly reported side effects include nausea, vomiting, diarrhea and constipation. Serious risks can include pancreatitis, gallbladder problems and, in animal studies, thyroid C-cell tumors. Review the full prescribing information and discuss your health history with a clinician.

Are compounded versions the same as brand-name medications?

No. Compounded drugs are not FDA-approved. Ask any provider exactly what medication and pharmacy they use.

Will insurance cover a GLP-1 medication?

Coverage varies widely by plan and diagnosis. Some programs help check your benefits or file prior authorization requests, but approval is never guaranteed.